Diagnostic Significance of Metabolic and Clinical Parameters in Disease Monitoring

Diagnostic Significance of Metabolic and Clinical Parameters in Disease Monitoring Department of Medical Biochemistry, Kharkiv National Medical University, Kharkiv, Ukraine Department of Medical Biochemistry, Cukurova University, Adana, Turkey Prof. Zhukov Victor Ivanovich,MD, PhD Prof. Nakonechna Oksana Anatolyevna, MD Prof. Abdullah Tuli, MD, PhD Prof. Levent Kayrın, MD, PhD Umut Kökbaş, MSc Tkachenko Anton Sergeyevich, PhD Moiseyenko Anton Sergeyevich, MD Ümit Yaşar, PhD Vasylieva Irina Mikhailovna, PhD Bagmut Irina Yuryevna, PhD Nowadays numerous modern monitoring and marker parameters of the functional state of the body and general homeostatic functions have appeared. The use of a wide range of new monitoring indices and markers with diagnostic and prognostic purposes requires analytical substantiation and compilation of them in disorders of metabolism and energy supply that may accompany the development of various diseases and pathological conditions. However, comprehensive analytical multisystem evaluation of disorders of homeostatic functions in various diseases and pathological conditions, using monitoring, metabolic parameters of the whole organism, organs, systems, and functions, has not yet been elaborated. This fact contributes to the appearance of this analytical manual that includes the use of scientifically based monitoring and marker indices for diagnosing disorders and pathological conditions of protein, lipid, carbohydrate, mineral, nucleic acid, water and salt, hormonal and pigment metabolism, acid-base balance, hemostasis, tumor and pregnancy markers, and enzymatic systems. This manual provides readers with information about reference ranges of marker and monitoring indices in blood, urine, cerebrospinal fluid, their elevation or reduction in case of one or the other disease and pathological condition of somatic, infectious, or genetic etiology. Informative metabolic and clinical parameters that are the most widely used for evaluating homeostatic functions in diseases of the cardiovascular, nervous, respiratory, digestive, urinary, endocrine, and reproductive systems, as well as blood, various organs and tissues from different sources have been analyzed and systematized. This manual provides analytical data about the 92 most common among the population diseases and pathological conditions with substantiated metabolic monitoring combinations of parameters, which can be used to make a diagnosis and monitor the efficacy of treatment. This analytical manual aims to help medical students, post-graduate students, researchers, and physicians to get information about monitoring parameters and markers in various diseases and pathological conditions: cardiovascular, nervous, respiratory, digestive, neuroendocrine, urinary, and reproductive systems, as well as disorders of protein, carbohydrate, lipid, water and salt, hormonal metabolism and metabolism of macro- and microelements, enzymes, pigments, dysfunctions of hemostasis and acid-base balance. It may also help to rapidly determine metabolic and clinical combinations of criterion-important parameters to diagnose and monitor the efficacy of treatment. Prof. Zhukov Victor Ivanovich